July 2008 Vol XXXII Issue 7

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The Impact of Non-alcoholic Fatty Liver Disease on Chronic Hepatitis B and C

Nila Rafiq, Zobair M. Younossi

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing due to the worldwide epidemic of obesity and diabetes. As the rate of obesity and NAFLD continues to increase, the impact of superimposed NAFLD and its risk factors on HBV and HCV must be better defined. This article gives the background of NAFLD, the pathogenesis and its impact on both hepatitis B and C.


Role of Biologics in Refractory Pouchitis

Carlo Calabrese, Giuseppina Liguori, Paolo Gionchetti, Fernando Rizzello, Veronica Gabusi, Rosy Tambasco, Giulia Straforini, Ramona Brugnera, Giulio Di Febo

The etiology of pouchitis is still unknown and its pathogenesis is still poorly understood. Recently it has been demonstrated that chronic refractory pouchitis may be associated with an unknown form of inflammatory disease of the ileum. The authors recap their study of treating patients with refractory pouchitis and extensive ileal involvement.


The Role of Food and Dietary Intervention in the Irritable Bowel Syndrome

Arthi Sanjeevi, Donald F. Kirby

Irritable bowel syndrome (IBS) has long been considered a diagnosis of exclusion. Diet can affect GI symptoms and this article examines the role of diet in both the possible genesis and treatment of IBS-related symptoms.


Fat Necrosis, Fibrosis, Chronic Inflammation, Abdominal Pain and a Small Bowel Mass in a 65-Year-Old Man

Wycliffe Okumu, C. Max Schmidt, Julia K. LeBlanc

The case is in the title. The patient was examined, tested by several methods including endoscopic ultrasound guided fine needle asperation (EUS-FNA) and diagnosed as having schlerosing mesenteritis, treated.

Departments Section

Brief Meetings Report


Demonstrate Clinical Utility of Cellvizio® GI in Diagnosing Colorectal Cancer and Barrett’s Esophagus

TAP Pharmaceutical Products Inc. Announces Phase 3 TAK-390MR Data Demonstrating Higher Overall Healing Versus Lansoprazole in Patients with Erosive Esophagitis

Additional Data Demonstrated Higher Overall Maintenance of Healed Erosive Esophagitis and Symptom Relief versus Placebo

Pivotal Study Shows Physician/Nurse Teams Using SedasysTMSystem Reduced Risk of Over Sedation with Propofol

Ethicon Endo-Surgery announced that the results from its pivotal trial demonstrated physician/nurse teams using the SEDASYS System reduced the risk of over sedation with propofol in patients undergoing screening and diagnostic procedures for colorectal cancer (colonoscopy), and disorders of the upper gastrointestinal tract (EGD).

Analysis of Ulcerative Colitis (UC) Time to Symptom Resolution Data from Pivotal Study of LialdaTM (Mesalamine) Presented at DDW

A post hoc analysis showing time to symptom resolution data from a study (study 302) of Shire plc’s ulcerative colitis (UC) drug, LialdaTM, was presented at Digestive Disease Week (DDW).

Study Presented at DDW 2008 Confirms that New Device Significantly Improves Detection of Polyps in the Colon

A study presented by Jerome D. Waye, MD, from the Mount Sinai Hospital in New York and principal investigator of the study, showed that the Third Eye RetroscopeTM, developed by Avantis Medical Systems, Inc. of Sunnyvale, CA, when used in combination with a standard colonoscope, detects a significantly higher number of adenomas and other polyps than the colonoscope alone.

Conservative Treatment of Infant GERD

Gastroesophageal reflux disease (GERD) is a relatively common problem in infants. Limited drug trials have been performed in this age group, and there is evidence to suggest that conservative management for infant GERD may be very efficacious for disease management.

Biliary Atresia: Is Mom to Blame?

Biliary atresia (BA) is the most common cause of liver transplant in infants, and its cause is essentially unknown although there appears to be an immunologic basis of the disease which may be autoimmune or infectious. In Japan, eight male infants with BA had their liver tissue compared to six male infants with liver disease from other causes, including hereditary tyrosinemia, choledochal cyst, congenital absence of the portal vein, hepatic hemangioendothelioma, and Crigler-Najjar syndrome.

Medical Bulletin Board

New Data Show High Frequency of Medical Claims for Gastrointestinal Events by Patients on Antiplatelet Therapy

Review of Insurance Claims Tracked Ulcers and Bleeding Among 368,000 Patients Prescribed Clopidogrel

Patients at Long-term Care Facilities Could Benefit from Yeast-based Probiotic

Clinical Evidence Shows that Use of Florastor® Can Reduce C. diff-Associated Disease Recurrence by Half; Manufacturer Introduces 200-Count Pack for Institutional Settings

Cimzia® Approved in the U.S. for the Treatment of Moderate to Severe Crohn’s Disease

Administered Every Four Weeks, UCB’s Pegylated Anti-TNFa Offers New Treatment Pption for Patients with Moderate to Severe Crohn’s Disease; Cimzia®

Radiofrequency Ablation is Effective Treatment for Dysplasia in Barrett’s Esophagus

Interim results from a nationwide clinical trial led by a University of North Carolina at Chapel Hill researcher suggest that radiofrequency ablation is an effective treatment for dysplasia in people with Barrett’s esophagus, a condition that can lead to deadly gastrointestinal cancer.