March 2009 Vol XXXIII Issue 3

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Introduction to a New Series

Rad M. Agrawal


Biliary Pancreatitis in Pregnancy

Vishal Jain, Balaji Yegneswaran, C.S. Pitchumoni

The spectrum of biliary disorders in pregnancy range from asymptomatic gallstone disease to serious necrotizing pancreatitis. The aim of this article is to present an update on gallstone disease and biliary pancreatitis in pregnancy.


Human Growth Hormone in Inflammatory Bowel Disease: Rationale, Evidence and Concerns

Marc Kaneshiro, Gil Y. Melmed

It is important that physicians and other health care professionals are aware of the specific indications for growth hormone and its potential for adverse effects. This article summarizes the rationale, evidence and side effect profile for human growth hormone use in IBD.


Enteral Feeding: Should It Be Continued in the Patient with Clostridium Difficile Enterocolitis?

Mark H. DeLegge, Amy Berry

The authors ask, "What evidence is there to support withholding of enteral feeding in the patient with C.diff?" They answer, "For now, there is no good physiologic reason that EN should be withheld in patients with active C. diff enterocolitis without clinical signs indicating that the clinician should do it."


The Coexistance of Crohnís Disease and Takayasu Arteritis: Diagnosis and Treatment of Combined Disease in Three Patients

Joel R. Judah, Chris J. Hammond, Steven F. Polyak, Walter E. Drane, John F. Valentine

A report on three patients with coexisting Crohn's Disease and Takayasu Arteritis. All three patients were treated with infliximab and this has not been previously described in the medical literature.


Anthony J. Nici

A case for you to solve.

Departments Section

Book Reviews

Curbside Consultation of the Liver: 49 Clinical Questions

This is the first edition of Curbside Consultation of the Liver which is authored by Dr. Mitchell Shiffman and members of his academic practice. Dr. Shiffman has authored or co-authored well over 200 articles, editorials, reviews, and book chapters and is a leader in hepatology. This text was constructed as a guide with concise answers to many routine clinical questions in hepatology.

From the Literature

HCV and Hepatobiliary and Pancreatic Cancer

A cohort study including 146,394 HCV-infected and 572,293 HCV-uninfected patients who received care at Veteran's Affairs Healthcare facilities, was conducted. Patients with two visits between 1996 and 2004 with HCV infection were included as were up to four matched HCV-uninfected subjects for each HCV-infected subject. Risks of intrahepatic cholangiocarcinoma (ICC), extra-hepatic cholangiocarcinoma (ECC), pancreatic cancer and hepatocellular carcinoma (HCC) were assessed using proportional hazards regression.

Transaminase Elevations in HIV Disease and Treatment

Liver damage associated with chronic unexplained high serum transaminases in HIV-infected patients under combined antiretroviral therapy has not been well characterized. Liver histology was prospectively investigated in patients presenting serum transaminase elevations for more than six months after exclusion of alcohol abuse, HCV or HBV infection, autoimmune and genetic liver diseases.

Medical Bulletin Board

PEGASYS® Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine

Largest Prospective Study Demonstrates Treatment Success, and Highlights Potential Factors that Affect Health Outcomes, in Latino Population Suffering from Chronic Hepatitis C

Restech Dx-pH Measurement System Accurately Measures Laryngopharyngeal Reflux in Children

Innovative pharyngeal pH probe helps differentiate baseline pH and potential etiology for various upper airway symptoms believed to be caused by acid reflux

Schering-Plough Completes Enrollment of Boceprevir Registration Studies in Treatment-Naive and Treatment-Experienced HCV Patients

Schering-Plough Corporation reports that it has completed patient enrollment in the boceprevir HCV SPRINT-2 study, a pivotal Phase III study in treatment-naïve patients. Together with the HCV RESPOND-2 study, a pivotal Phase III study in patients who failed prior treatment that completed enrollment in November 2008, the company has fully enrolled its registration studies for boceprevir, its lead investigational oral hepatitis C protease inhibitor. A total of more than 1,500 patients were enrolled in these studies at U.S. and international sites.