June 2009 Vol XXXIII Issue 6

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Diabetic Gastroparesis: A Review of Medical Treatments

Reza A Hejazi, Richard W. McCallum

Treatment of diabetic gastroparesis is based on symptom severity. A new oral disintegrating tablet formulation of metoclopramide is being developed that is expected to be valuable therapy for patients with gastroparesis.


Wernicke's Encephalopathy: Role of Thiamine

Allan D. Thomson, Irene Guerrini, E. Jane Marshall

Wernicke's encephalopathy is a neuropsychiatric disorder which arises from thiamine deficiency. This article provides recommendations for the prophylactic treatment as well as treatment for suspected cases of Wernicke's encephalopathy.


Abdominal Wall Metastasis After PEG Placement in Patients with Oropharyngeal Cancer

Tarun Narang, Stacy Ugras, Mark Pochapin, Michael Lieberman

A case of a patient with stage 4 squamous cell cancer at the base of his tongue who developed a metastatic lesion at the gastronomy site ten months after PEG placement.

Departments Section

From the Literature

Perforated Diverticular Disease

To determine the incidence and mortality associated with diverticular perforation and the incidence of comorbidity, a population-based cohort study was carried out using patients with that disorder and population controls identified from 1990 to 2005 in the general practice research database. Incidence and mortality rates were models using Poisson and Cox regression. Comorbidity was quantified using the Charlson Index.

Gastrointestinal Transit Dysfunction in Cirrhosis

Liver cirrhosis is associated with increased prevalence of gastrointestinal symptoms, insulin resistance and altered gut transit. To assess the prevalence of gut transit abnormalities in patients with cirrhosis, compared with healthy controls and to evaluate the relation of gut transit with gastrointestinal symptoms and postprandial glucose and hormone profiles, gastric emptying, small bowel residence and colonic filling times were measured with a validated radiologic procedure in 42 patients with cirrhosis.