July 2010 Vol XXXIV Issue 7

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It's Not Just About the Gut: Managing Depression and Anxiety in Inflammatory Bowel Disease

Lesley A. Graff, John R. Walker, Charles N. Bernstein

Higher rates of anxiety and depressive disorders have been found in individuals with inflammatory bowel disease, and these conditions can have a detrimental effect on disease course. Here, we discuss practical recommendations for managing these conditions when treating the patient with IBD, including consideration of screening and initiating evidencebased pharmacological or psychological treatment.


Drug Therapy-Related Issues in Patients Who Received Bariatric Surgery (Part I)

Lingtak-Neander Chan

With the number of bariatric surgical procedures performed on the rise, clinicians will inevitably be involved in the care of patients who have received one of these procedures. The objectives of this article are to review the process and factors that affect drug absorption from the GI tract, discuss the existing data on how bariatric procedures affect pharmacokinetics, dispel misconceptions regarding how the bariatric procedures alter drug disposition, and discuss other pertinent pharmacotherapy-related issues in patients who have undergone bariatric surgery.


Abdominal Lymphadenopathy as the Initial Presentation of Sarcoidosis

Kashif Tufail, Nikroo Hashemi

Here, we report a case of sarcoidosis presenting with abdominal lymphadenopathy, without involvement of the abdominal viscera.


Janani Mohan, Balaji Yegneswaran

A case for you to solve.

Departments Section

From the Pediatric Gastroenterology Literature

Mutations Causing Early-Onset Inflammatory Bowel Disease

The molecular and genetic causes of inflammatory bowel disease (IBD) are just beginning to be elucidated. The authors of this study from Hannover, Germany and London, England evaluated patients with early-onset IBD (diagnosed prior to one year of age).

Using Rectal Sensory Threshold for Pain to Diagnose Childhood IBS

Visceral hypersensitivity is defined as an exaggerated pain response to a peripheral stimulation such as intestinal lumen distention. Recent studies have suggested that rectal hypersensitivity may be associated with childhood irritable bowel syndrome (IBS) and functionalabdominal pain (FAP), which are distinct disorders categorized as functional gastrointestinal disorders (FGID) in children.

Is the Pediatric Obesity Rate Changing?

Pediatric gastroenterologists are involved in the care of pediatric obese patients either by treating GI-associated complications (GERD, steatohepatitis) or directing obesity clinics. The increased prevalence of this disease has profound implications on the long-term viability of the United States health care system. The authors of this study from the Centers for Disease Control and Prevention evaluated high body mass prevalence between 1999 through 2008.

Medical Bulletin Board

New Adjustable Intragastric Balloon Appears Well-Tolerated, Demonstrates Significant Weight Loss

Spatz-FGIA to Present Clinical Data at DDW 2010
A new adjustable intragastric balloon appears to help obese patients lose significant amounts of weight and could be more tolerable than traditional intragastric balloons which must be removed after six months.

OraSure Technologies Receives FDA Approval for OraQuick®HCV Rapid Test, the First Rapid HCV Test Approved for Sale in the U.S.

OraSure Technologies, Inc. announced today that its OraQuick® Hepatitis C ("HCV") Rapid Antibody Test has been approved by the U.S. Food and Drug Administration ("FDA") for use in detecting HCV antibodies in venous whole blood specimens, making it the first rapid HCV test approved by the FDA for use in the United States.