August 2010 Vol XXXIV Issue 8

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Clostridium difficile Associated Disease in the Older Adults

C.S. Pitchumoni, Harshit S. Khara

In older adults, Clostridium difficile associated disease has emerged as the most frequent nosocomial infection with substantial morbidity, mortality and economic burden to healthcare. This review discusses the epidemiology, risk factors, bacteriology, clinical manifestations, diagnostic modalities, prevention and treatment of CDAD.


Drug Therapy-Related Issues in Patients Who Received Bariatric Surgery (Part II)

Lingtak-Neander Chan

With the number of bariatric surgical procedures performed on the rise, clinicians will inevitably be involved in the care of patients who have received one of these procedures. The objectives of this article are to review the process and factors that affect drug absorption from the GI tract, discuss the existing data on how bariatric procedures affect pharmacokinetics, dispel misconceptions regarding how the bariatric procedures alter drug disposition, and discuss other pertinent pharmacotherapy-related issues in patients who have undergone bariatric surgery.


Combination Weight-based Pegylated Interferon alfa-2b and Ribavirin for Chronic Hepatitis C: Impact of Genotype and Race

Shyam Thakkar, Sankar Alagugurusamy,Vinay Mehta, Martha Loeffert, Michael Babich, Radheshyam Agrawal

Over the past decade, there have been several advancements in the treatment of Hepatitis C virus infection. This retrospective, single-center study determined the efficacy of weight-based PEG-IFN alfa-2b (1.5 mg/kg/wk) plus weight-based ribavirin therapy (13 mg/kg/d) in 80 patients. Sustained virologic response was calculated overall, by race and by genotype. Results were compared to previous studies that found the highest SVR rates with combination therapy.

Departments Section

Medical Bulletin Board

Exalenz Bioscience and Sandhill Scientific Partner to Deliver Advanced Breath Testing Solutions for H. pylori Assessment to the Gastroenterology Market

Sandhill Scientific to Distribute Exalenz's BreathID®c; System Nationally Exalenz Bioscience, Inc., a medical device company specializing in the diagnosis and monitoring of gastroenterological and liver related diseases, today announced it has entered into a multi-year, strategic relationship with Sandhill Scientific, Inc., a leading manufacturer and marketer of innovative gastroenterology devices, to promote the BreathID®c; Breath Test System and Exalenz' full line of H. pylori diagnostic solutions to gastroenterologists throughout the United States.

Recipients of the 2010 Young Investigator Grant for Probiotics Research Announced The Global Probiotics Council Continues to Fund Rising Stars

The Global Probiotics Council (GPC), a committee established in 2004 by Danone and Yakult Honsha Co., Ltd., announced the two recipients of the third annual Young Investigator Grant for Probiotics Research (YIGPRO) today. The program was created to contribute to the advancement of probiotics and gastrointestinal microbiota research in the United States. The gastrointestinal microbiota is made up of trillions of live microbes that inhabit the human body and participate in numerous functions such as digestion, immune system development and protection from pathogens.