November 2011 Vol XXXV Issue 11

Previous MonthNext Month

Nutrition Issues in Gastroenterology, Series #100

Severe Micronutrient Deficiencies in RYGB Patients: Rare but Potentially Devastating

Kelly O’Donnell

Here we discuss vitamin and mineral deficiencies occurring after Roux-en-y gastric bypass and their potentially devastating side effects.

Inflammatory Bowel Disease, Series #74

Preventing Postoperative Crohn?s Disease with Anti-TNFs:

Dario Sorrentino

Recent promising data have shown that postoperative recurrence can be prevented in between 90 and 100% of patients when anti-tumor necrosis factor (TNF) are given immediately after surgery. This review will focus on the published studies that have used anti-TNFs to prevent postoperative recurrence, outline possible long-term strategies for these patients and review the potential implications of these data.

A Special Article

A Critical Review of Coffee Consumption and Gallstone Disease

Arush Singh, C. S. Pitchumoni

Coffee drinking is almost universal and is gaining a reputation as a functional food. In particular coffee consumption is noted to reduce gallstone disease. In this paper the authors review the data on coffee consumption and the prevalence of gallstone disease.

CORRECTION We regret an oversight in this article, "A Critical Review of Coffee Consumption and Gallstone Disease" by Arush Singh and Dr. C.S. Pitchumoni. On page 43, the first sentence of the second paragraph of the "Inconclusive Studies" section read: "Another study attempted to analyze why Danish individuals had roughly double the rates of gallstone disease than their nearby northeastern German counterparts." The correct sentence is: "Another study attempted to analyze why Danish individuals had roughly half the rate of gallstone disease than their nearby northeastern German counterparts." The Editors

A Case Report

Endoscopic Diagnosis and Treatment of Stercoral Colitis

Seth A. Cohen, Gil Ascunce, Franklin E. Kasmin, David Carr-Locke

Stercoral colitis is usually only recognized post hoc in its most severe clinical manifestation when it has already led to perforation and peritonitis requiring surgical exploration. Here we present three cases diagnosed endoscopically.

Departments Section

From the Pediatric Literature

Vitamin E, Metformin, and NAFLD in Children

As a consequence of the pediatric obesity epidemic, non-alcoholic fatty liver disease (NAFLD) has become a significant public health issue. Over time, pediatric NAFLD runs the risk of developing into cirrhosis and hepatocellular carcinoma as children progress into adulthood.

Is a Biopsy Needed to Diagnose Celiac Disease in Children?

Celiac disease (CD) is very common in northern European children, and it has been shown to have a high prevalence in United States children as well. Due to the invasive aspect and cost of esophagogastroduodenoscopy with biopsy to confirm a diagnosis of CD, the authors of this study evaluated the efficacy of detecting CD based on serum testing alone.

Hepatitis C Treatment in Children

Treatment recommendations for hepatitis C virus (HCV) infection are defined for adult patients; however, no such guidelines exist for treatment of HCV in children. Approximately 40,000 children are infected with HCV in the United States, and medical treatment is necessary to prevent serious sequelae such as hepatocellular carcinoma and liver transplantation.

The Changing Clinic Presentation of Pyloric Stenosis

Hypertrophic pyloric stenosis (HPS) is a common clinical problem leading to pyloromyotomy in order to relieve vomiting from gastric outlet obstruction in young infants. The classic electrolyte findings seen in HPS include hypochloremic, hypokalemic metabolic alkalosis which can lead to morbidity and prolonged hospitalization. The use of abdominal ultrasound (US) imaging may detect HPS at a younger age which makes biochemical testing unreliable as HPS may be diagnosed early in its evolution. The authors of this study reviewed all cases of HPS over a three-year period at The Hospital for Sick Children, University of Toronto.

Medical Bulletin Board

Transgene and Jennerex Announce the First Patient Randomized in Phase IIb Clinical Trial of JX594/TG6006 in Liver Cancer

Strasbourg, France, and San Francisco, California, November 4, 2011 ? Transgene (Euronext Paris: FR0005175080) and Jennerex, Inc. today announce that enrollment has been initiated and the first patient has been randomized in a Phase IIb clinical trial called TRAVERSE. The trial is evaluating the use of JX594/ TG6006 to treat patients with advanced liver cancer, also known as hepatocellular carcinoma (HCC), who failed prior therapy with Nexavar® (sorafenib), the only approved drug for HCC.

Holiday Eating and GERD: The Facts About Symptoms and When to See a Doctor

Oak Brook, Ill. The holiday season is fast approaching and for approximately 30 million Americans with gastroesophageal reflux disease, or GERD, celebrations can be less than festive when holiday eating becomes uncomfortable. National GERD Awareness Week is November 20-26, and the American Society for Gastrointestinal Endoscopy urges individuals who suffer from GERD to seek medical diagnosis and treatment to make their holidays and every day comfortable and symptom-free.