July 2012 Vol XXXVI Issue 7
Nutrition Issues in Gastroenterology, Series #107
When the Bowel Becomes the Bladder: Changes In Metabolism after Urinary DiversionAdvances in surgical techniques and in medical therapy have resulted in long life expectancy after urinary diversion at present. Here we discuss the importance of addressing evident and severe metabolic problems after urinary diversion and paying attention to the more discrete changes in metabolism that can affect quality of life in the long run.
Practical Approaches to the Diagnosis and Treatment of Colorectal Cancer, Series #5
Opportunities and Limitations of Blood-Based CRC Screening TestsApproximately one-third or 35 million eligible individuals in the United States still do not actively participate in any colorectal cancer (CRC) screening screening program, falling considerably short of the American Cancer Society?s nationwide goal to reach a CRC screening rate of 75% by 2015. Recently, blood-based tests have entered the market in both the United States and Europe. This review discusses these newly available tests, their potentialand the challenges they must overcome for success.
Diseases of the Pancreas, SERIES #6
Genetic Mutations, Polymorphisms and PancreatitisHereditary chronic pancreatitis is a rare form of pancreatitis with a typical early onset and a slow progression of disease. The significant increase of pancreatic cancer in this patient population is very concerning. There has been remarkable progress in understanding the genetic basis of chronic pancreatitis. In this paper, we will review the underlying genetic factors and their link to chronic pancreatitis.
A Case Report
Endoscopic Hemoclip Application in a High-Risk Pediatric Patient with Gi Bleeding Following Endoscopic BiopsyDepartments Section
HIV and Liver Disease
HIV and Liver Disease is a well-organized and comprehensive book reviewing liver disease in people with HIV, with a particular focus on viral hepatitis. This book originated from a series of NIH-supported conferences designed to bring together a transdisciplinary group of experts to address liver disease in people with HIV.
Eosinophilic Esophagitis
Christopher Liacouras and Dr. Jonathan Markowitz is a comprehensive collection of over 30 chapters on eosinophilic esophagitis (EoE). In fact, this is the first textbook dedicated to this emerging and increasingly recognized entity that affects people of all ages from early childhood to adulthood.
Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions
GI cancers are increasingly becoming a major part of gastroenterology practice, and gastroenterologists now play a vital role in the management of these patients. Early diagnosis, accurate staging and increasing multidisciplinary management of these cancers require a thorough working knowledge. For a busy clinician or gastroenterology fellow, it is somewhat challenging and cumbersome to assimilate the required knowledge from traditional references and oncology textbooks. This book serves as a unique and concise reference for the diagnosis, staging and treatment of various gastrointestinal neoplasms. Even though the book?s title is targeted towards gastroenterologists, this book is ideal for gastroenterologists, surgeons, medical oncologists, fellows (gastroenterology, surgery, oncology), and radiology residents involved in the management of patients with GI cancers.
Rifaximin in Producing Remission in Crohn?s Disease
Approximately 10 percent of patients with reflux esophagitis (RE) are not cured with a standard 8 week daily regimen with a PPI. Thus, twice a day dosing is often used in refractory RE (rRE) patients. This study was carried out to assess the efficacy and safety of 8-week therapy with rabeprazole (RPZ) at 20 mg twice a day or 10 mg twice a day as compared with RPZ at 20 mg daily in patients refractory to the standard PPI regimen in Japan.
Ethnicity and NAFLD
Investigation of relationships between ethnicity and nonalcoholic fatty liver disease (NAFLD) severity, metabolic derangement and socio-demographic characteristics was studied in a well-characterized cohort of adults with biopsy-proven NAFLD. Data was analyzed from 1,026 adults 18 years or older from 2004 to 2008, from which liver histology data was available within6 months of enrollment.
Testosterone and HCV Hepatitis
The association between testosterone and HCV related advanced liver disease was evaluated in a cross-sectional study in male veterans with chronic HCV. Blood samples were obtained to measure total serum testosterone and perform the Fibro-SURE ActiTest. Other risk factor data was obtained through systematic questionnaires, including alcohol, physical measurements (BMI), and serologic tests (e.g., viral load). The association between total testosterone and risk of advanced hepatic fibrosis (F3 and F4), as well as inflammatory activity (A3 and A2-3), measured by that test were evaluated with logistic regression.
Efficacy of Radiofrequency Ablation for Hepatocellular Carcinoma
To report a 10-year consecutive case series at a tertiary referral center of radiofrequency ablation (RFA), a total of 2,982 RFA treatments on 1,170 primary HCC patients were performed and analyzed and a collected database was reviewed.
Capsule Endoscopy Detection Rates
The objective of this study was to compare the detection rates of clinically significant findings in different capsule endoscopy reading modes and speeds. Seventeen capsule endoscopists with experience from 23 to greater than 1000 total capsule procedures read 24 clips, 18 of which were abnormal. Clips were read in two different reading modes, utilizing two speeds, including single view at 15 AT frames per second and single view 25 FPS, quad-view 20 FPS and quad-view 30 FPS.
Rabeprazole Twice Daily for Refractory Reflux Esophagitis
Approximately 10 percent of patients with reflux esophagitis (RE) are not cured with a standard 8 week daily regimen with a PPI. Thus, twice a day dosing is often used in refractory RE (rRE) patients. This study was carried out to assess the efficacy and safety of 8-week therapy with rabeprazole (RPZ) at 20 mg twice a day or 10 mg twice a day as compared with RPZ at 20 mg daily in patients refractory to the standard PPI regimen in Japan.
Incident Pancreatic Lesions Identified in Asymptomatic High-Risk Individuals
The risk of pancreatic cancer is increased in patients with a strong family history of pancreatic cancer or a predisposing germ line mutation. The optimal imaging approach is not known. To determine the baseline prevalence and characteristics of pancreatic abnormalities using 3 imaging tests to screen asymptomatic, high-risk individuals, 225 asymptomatic adult HRIs were screened at five academic US medical centers, once using computed tomography (CT) magnetic resonance imaging (MRI), and endoscopic ultrasonography (EUS). Results were compared in a blinded, independent fashion.
Pernix Therapeutics Introduces Omeclamox-Pak®,First Product in Gastroenterology Portfolio
Omeclamox-Pak® eradicates Helicobacter pylori bacteria infection in just ten days
Cedars-Sinai physician definitively links irritable bowel syndrome (IBS) and bacteria in gut
Clinical trials showing antibiotics are an effective treatment for IBS
