February 2013 Vol XXXVII Issue 2

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Nutrition Issues in Gastroenterology, Series #114

Nutritional Management of the Adult with Cystic Fibrosis ? Part II

Christie L. Rogers

This is part II of a two part series which serves to present the nutritional challenges of adults with cystic fibrosis and to provide tools to prevent or manage these major nutritional concerns. Here we address cystic fibrosis related diabetes, fertility, and pregnancy with cystic fibrosis.

Inflammatory Bowel Disease: A Practical Approach, Series #79

Management and Surveillance of Dysplasia in Inflammatory Bowel Disease

Veena Nannegari, Rachana Potru, Jesse Green

Surveillance for dysplasia and cancer should begin after 8 years of disease. This review will outline epidemiology, pathology, management of colon cancer in ulcerative colitis and Crohn?s disease and the evidence supporting a role for cancer surveillance.

Hepatitis c: a New era of Treatment, Series #6

Implications of the 2012 Centers for Disease Control and Prevention (CDC) Guidelines for Screening Hepatitis C Infection in the United States

Patrick M. Horne, Rennie Mills

In the United States, the majority of patients with chronic Hepatitis C (HCV) contracted the virus as a result of contaminated blood product transfusions prior to 1992 or due to intravenous drug use (IVDU). Recent guidelines released by the Centers for Disease Control and Prevention (CDC) have addressed this issue. This review discusses risk factors for contracting HCV, potential implications of the CDC guidelines, the importance of screening and the impact these new guidelines will have on healthcare providers (HCP).

A Case Report

Regression of Mucosa-Associated Lymphoid Tissue (Malt) Lymphoma of the Cecum After Eradication of Helicobacter Pylori

Manish Prasad Shrestha, Tat-Kin Tsang

A Case Report

Meat And Cola: An Esophageal Bezoar Treated by a Novel, Inexpensive Approach

Adam C. Adler, Cesar Cestero, Eddy A. Castillo

Departments Section

From the Literature

FIT to Evaluate Mucosal Healing in UC

To determine whether a fecal immunochemical test (FIT) can evaluate mucosal healing in ulcerative colitis (UC), feces collected from UC patients who underwent colonoscopy were examined by FITs and results were compared with colonoscopic findings. Mucosal status was assessed using the Mayo Endoscopic Subscore classification. Maximum score for the colorectum in each patient was recorded.

H. Pylori-Negative Gastritis

To investigate the prevalence of H. pylori among individuals with histologic gastritis, subjects between 40 and 80 years of age underwent elective EGD at a VA Medical Center. Gastric biopsies were mapped from seven prespecified sites (two in the antrum, four in the corpus, and one in the cardia), and graded by two gastrointestinal pathologists, using the updated Sydney System.

Surveillance of Longstanding Achalasia

In early recognition of the need for retreatment in achalasia is of crucial importance to reduce morbidity and long-term complications. In order to decide which tests perform best for evaluation of same, a cohort of 41 patients with longstanding achalasia (median 17 years), underwent esophageal manometry, timed barium esophagogram and symptom evaluation. Patients were followed up to ten years, and were regarded as a therapeutic failure if Eckhardt score was greater than 3, or when retreatment was needed. Predictors of therapeutic failure were evaluated.

Book Reviews

Self-Expanding Stents in Gastrointestinal Endoscopy

In the recently published text Self-Expanding Stents in Gastrointestinal Endoscopy, Editor Douglas G. Adler takes an evidence-based exploration of the use of selfexpanding stents throughout the gastrointestinal tract. Each of the 14 chapters details the indications for use, available stent options, technical deployment methods, and potential complications and their maagement by leading authors in their field.

From the Pediatric Literature

Cow?s Milk Avoidance Alone for Treatment of Eosinophilic Esophagitis

Eosinophilic esophagitis (EoE) is likely exacerbated by both dietary antigens and inhaled aeroallergens. In order to induce remission of symptoms, many patients undergo a directed elimination diet to see if they will clinically improve with control of symptoms and decreased eosinophilic infiltration of the esophagus. The authors of this study evaluated the outcome of pediatric patients with EoE who underwent cow?s milk elimination as the sole dietary intervention.

A Fecal Biomarker for Necrotizing Enterocolitis

Necrotizing enterocolitis (NEC) is a devastating intestinal disease seen in premature infants. It has a very high mortality rate, and its pathogenesis is unknown although bowel ischemia, intestinal bacterial translocation, and an impaired immune system may contribute to the disease. The diagnosis of NEC is often delayed leading to severe consequences, and the authors of this study attempted to determine if the fecal biomarker, S100A12 (calgranulin C), could be used to be a screening test for NEC. S100A12 is a type of damage-associated molecular pattern protein that is released when cells are damaged and is resistant to bacterial degradation.

Medical Bulletin Board

Oral Cancer Prevention International and CDx Laboratories Merge To Form CDx Diagnostics

New Company to Market Innovative Diagnostic Tools that Enable Prevention and Earlier Detection of Oral, Laryngeal and Esophageal Cancers-Strong Pipeline of New Tests for Liver, Pancreatic and Colon Cancer will Create Additional Value

Altheus Therapeutics Announces First Patient in Phase 2 Ulcerative Colitis Trial of Zoenasa®

Altheus Therapeutics announced today it has randomized its first patient in a comparator-controlled Phase 2 efficacy study of Zoenasa®, a novel combination therapy for ulcerative colitis (UC).

Surgeons at Sun Coast Bariatrics are the first in the Tampa Bay area to offer a single-incision sleeve gastrectomy procedure for patients seeking to lose weight.

Dr. Tiffany Jessee, a nationally recognized leader in bariatric surgery, and her colleague, Dr. Robyn Ache, are using the SPIDER® Surgical System to perform the weight-loss procedure through a small, single incision made near the patient’s belly button ? resulting in a virtually invisible scar.