August 2014 Vol XXXVIII Issue 8

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Epidemiology of Gastrointestinal Cancers, #4

Epidemiological Spectrum of Gastrointestinal Lymphoma

Sarfaraz Jasdanwala, C.S. Pitchumoni

Epidemiology of GI lymphomas differs substantially in different geographical regions of the world. Most population based studies have been done in Asian and European patients, with very few studies from North American cohorts. Also, a huge difference exists in the prevalence and epidemiology of GI lymphomas in different anatomical regions of the GI tract. The aim of this review is to provide data on the complex epidemiology of GI lymphoma as part of the present series on cancers of the GI tract.

Nutrition Issues in Gastroenterology, Series #132

Short Bowel Syndrome in Adults - Part 1

John K. DiBaise, Carol Rees Parrish

Short bowel syndrome (SBS) is a malabsorptive condition resulting most commonly from extensive intestinal resection. The management of patients with SBS is complex and requires a multidisciplinary approach including dietary, fluid and pharmacological management, co-morbid disease management and, occasionally, surgery. In Part 1 of this five-part series on SBS, we address the physiological alterations that occur, the clinical consequences of these changes including potential complications, and the adaptation process that the intestine undergoes in order to improve the bodyís ability to digest and absorb nutrients and fluid.

Unusual Causes of Abdominal Pain, #5

Unusual Causes of Abdominal Pain

George W. Meyer

A Case Report

Poorly Differentiated Cecal Adenocarcinoma Presenting as Metastatic Disease to the Bone

J.K. Deutsch, N. Suda, P. Balachandran

Departments Section

From the Literature

HCV Genotype III, Cirrhosis and HCC

Data shows that viral Genotype I may increase the risk of cirrhosis and hepatocellular carcinoma (HCC), compared to Genotype II in patients with chronic HCV. To determine the effect of Genotype III on cirrhosis and HCC risk, patients were identified with active HCV infection, confirmed by PCR and a known HCV Genotype, from the VA HCV Clinical Case Registry between 2000 and 2009. The effect of HCV Genotype on the risk of cirrhosis and HCC was examined in a Cox Proportional Hazards Model

Hereditary Diffuse Gastric Cancer and Endoscopic Surveillance

Prophylactic total gastrectomy is performed in hereditary diffuse gastric cancer (HDGC) patients carrying the CDH1 mutation because endoscopic surveillance often fails to detect microscopic disease. To determine the natural history and outcomes of patients with HDGC undergoing endoscopy, a prospective cohort observational study was carried out at a tertiary referral center.

Chronic Hepatitis B-Related HCC Decreased with Treatment

A retrospective, nationwide cohort study using data from Taiwan’s National Health Insurance Research Database from 01/01/1997 through 12/31/2010 was conducted. Cumulative incidences were calculated and multivariable analyses were carried out after adjusting for competing mortality.

Stool DNA Testing for Colorectal Cancer Screening

A noninvasive, multi-target stool DNA test was compared with fecal immunochemical test (FIT), in patients at average risk for colorectal cancer. The DNA test included quantitative molecular assays for KRAS mutations, aberrant NDRG4 and BMP3 methylation, and B-Actin, plus a hemoglobin immunoassay.

Duodenal Intraepithelial Lymphocytosis

Increased intraepithelial lymphocytosis (IEL) with preserved villous architecture is a common, yet nonspecific finding on duodenal biopsies. To study the change in frequency of isolated IEL and duodenal biopsy over time and determine whether previously reported disease associations have changed during that period, a retrospective study at a single tertiary-care referral center was carried out

Adenoma Detection Rate and Risk of Colorectal Cancer

To determine the association between the rate and patient’s risks of subsequent colorectal cancer (interval cancer), and death, data from an integrated healthcare delivery organization was evaluated.

Effects of Treatment for Biliary Dyskinesia

To determine whether endoscopic sphincterotomy reduces pain and whether sphincter manometric pressure is predictive of pain relief in the presence of abdominal pain after cholecystectomy, a multicenter, sham- controlled, randomized trial involving 214 patients with pain after cholecystectomy...

Treatment of Acute Hepatitis C

An open, randomized, multicenter trial to assess the efficacy and safety of a 24-week course of PEG-IFN Alpha-2B versus a 12-week course of same or with ribavirin (RBV) in acute hepatitis C (AHC) patients was carried out.

SSRI And Risk of Gastrointestinal Bleeding

To obtain a more precise estimate of the risk of upper GI bleeding with SSRIs, with or without concurrent NSAID use, a search was made through MEDLINE EMBASE Psyc-Info, the Cochrane Central Register of Control Trials through April 2013 and the US and European Conference proceedings was carried out.

Medical Bulletin Board


WELLINGTON FL - Mission Critical Health signs agreement with Hepatitis Foundation International to develop a series of evidence based liver health educational videos.


A novel study reveals that more than half of liver transplant patients want to be informed of donor risk at the time a liver is offered for transplantation.

Meetings Calendar

September 16, 2014 Raising C Diff Awareness Conference
October 8-11, 2014 77th Annual University of Minnesota Colon and Rectal Surgery: Current Principles & Practice
October 17-22, 2014 ACG Annual Scientific Meeting and Postgraduate Course