November 2015 Vol XXXIX Issue 11

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Endoscopic Cryotherapy: Indications and Efficacy

Sylvia Nai-Yu Hu and Douglas G. Adler

Although widely used in various fields of medicine, cryosurgery is a relatively new addition to the endoscopic armamentarium. Endoscopic cryoablation has been used in esophageal dysplasia and cancer, to treat bleeding caused by gastral antral vascular ectasia (GAVE) and radiation proctitis, and in other contexts. This manuscript will review the current applications of endoscopic cryotherapy as well as their efficacy and safety.


Efficacy, Safety and Tolerability of Rectal Therapies in Ulcerative Proctitis and Ulcerative Proctosigmoiditis A Special Supplement

Elisa McEachern and Brian P. Bosworth

Ulcerative colitis (UC) is a chronic condition in which inflammation extends proximally from the rectum along the colonic mucosa. Most patients experience alternating periods of active disease and clinical remission. In patients with ulcerative proctitis or ulcerative proctosigmoiditis, inflammation is limited to the rectum, or rectum and sigmoid colon, respectively. Induction of clinical remission is the primary goal of treatment for patients with active UC, whereas maintenance therapy is recommended for patients with UC in remission.


Syphilitic Hepatitis

Lauren M. Bleich and Howard L. Taubin

Departments Section

Book Reviews

The Gut Balance Revolution

The Gut Balance Revolution is presented as a three- step plan to rebalance the gut microbiome, with the goal of improved health and loss of excess weight. The goal of step 1 is to decrease overall gut bacteria and reduce systemic inflammation, using methods such as induced ketosis and removal of gluten from the diet. Step 2 aims to 'reestablish a thriving gut microbiome' by incorporating a variety of fermented foods and reintroduction of specific foods into the diet. Weight maintenance and 'optimal health' are the goals of step 3.

Celiac Disease and Other Small Bowel Disorders

This book is published as a reprint of the official congress report of the Falk Symposium, and the stated purpose is to 'enhance awareness of celiac and other small bowel disorders.' It is composed of twenty-seven articles from various thought leaders with topics ranging from the immunology of the small bowel to non-celiac gluten sensitivity to novel therapies. While attempting to cover a very broad range of subject matter, the organization of the articles makes it a useful book that is read easily and quickly. The reader notes very little redundancy. Well grounded in current literature and scientific understanding, almost all of the chapters are well written and focused to the point of efficiently conveying necessary information without overwhelming the reader with excessive background.

From the Pediatric Literature

IBD in the Very Young

Inflammatory bowel disease (IBD) in children appears to be increasing in prevalence, and the authors of this study evaluated the natural history of a specific subset of pediatric IBD, very early-onset (VEO)-IBD which is defined as IBD occurring in children less than 6 years of age. Data were obtained from the Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry, which is a multi-center, prospective study evaluating the natural history of pediatric IBD. All study patients underwent a physician global assessment at baseline and then annually. Clinical characteristics were obtained at baseline, 30 days after diagnosis, and then every 3 months. A diagnosis of Crohn disease (CD), ulcerative colitis (UC), and IBD-unclassified (IBD-U) was determined using standard laboratory, radiologic, endoscopy, and histology criteria. Extent of disease was described using the Montreal Classification system, and additional data collection included IBD treatments and hospitalizations.

Liver Transplant Volume and Subsequent Transplantation Outcome

Low surgical procedure volume is associated with poor outcomes, and this relationship potentially exists when considering solid organ transplantation in children. This study specifically looked at medical center procedural volume in relation to pediatric organ transplantation wait list time and procedural outcome. This 10 year retrospective study of pediatric liver transplant patient UNOS (United Network for Organ Sharing) data evaluated patient characteristics at time of transplant, 6 months after transplant, and then annually. Low-volume transplant centers were defined as having performed less than 5 cases annually. The primary outcome measure of the study was death (post-transplant or while still on the wait list).

Medical Bulletin Board


Minneapolis, MN - Medspira has received US Food and Drug (FDA) 510K clearance for its mcompass biofeedback/pelvic floor retraining system. Pelvic floor therapy coaches/retrains patients to properly utilize their pelvic floor muscle functions to help control constipation or fecal incontinence symptoms.


Does A Family History of Cancer Increase Your Odds of Getting the Disease?

Meetings Calendar

December 10-12, 2015 2015 - Advances in Inflammatory Bowel Diseases, Crohn's & Colitis Foundation's Clinical & Research Conference
January 21-23, 2016 - Gastrointestinal Cancers Symposium Insight on Novel Mechanisms and Precision Care
February 6, 2016 - 4th Annual Advances in Gastroenterology and Hepatology