December 2017 Vol XLI Issue 12

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INTRODUCTION TO A NEW SERIES: THE MICROBIOME AND DISEASE

The Microbiome and Disease

Sabine Hazan



THE MICROBIOME AND DISEASE, SERIES #1

The Microbiome and Clostridium difficile

Sabine Hazan, Daniel Frochtzwajg, Jessica Murray

A new, emerging paradigm suggests that the susceptibility, severity, and duration of some diseases, even some previously thought to be independent of microbial involvement, are mediated by a complex interplay of host and microbe genomes. Already, nearly 10 million different microbial genes have been isolated from the human gut. In this series, we aim to shed light on some of the most promising research to date that addresses the intestinal microbiome as it relates to common chronic diseases.



NUTRITION ISSUES IN GASTROENTEROLOGY, SERIES #170

Have PN (Parenteral Nutrition) - Will Travel

Anna Patsy, Adriana Panciu, Nizar Senussi

Patients requiring long term parenteral nutrition (PN) may choose to travel at some point. Traveling with PN requires collaboration among the patient, prescriber, and the infusion pharmacy. Coordination of PN deliveries and supplies, as well as managing clinical concerns and safety, must be addressed prior to traveling. Self-monitoring, as well as necessary lab tests must be coordinated to effectively monitor electrolytes and hydration. Knowing how to reach their providers and where medical facilities are located in the event that an emergency should arise is important. While traveling with PN can sometimes be challenging to coordinate, it should not discourage medically stable patients from doing so. This article provides suggestions to clinicians to help their HPN patients travel safely.



INFLAMMATORY BOWEL DISEASE: A PRACTICAL APPROACH, SERIES #104

Management of the Ileal Pouch-Anal Anastomosis in the Elderly

Irving Levine, Shannon Chang

The ileal pouch-anal anastomosis (IPAA) has become standard of care in maintaining fecal continence after colectomy. Select elderly patients are now candidates for IPAA surgery. When caring for these patients, many of the medications prescribed for management of pouchitis or diarrhea should be used with caution, with or without dose adjustments. Other special considerations in the elderly population include history or use of radiation therapy, dysplasia surveillance, and sphincter dysfunction. In this article, we review the medical management and functionality of pouches in the elderly population.



GASTROINTESTINAL MOTILITY AND FUNCTIONAL BOWEL DISORDERS, SERIES #23

Gastroesophageal Reflux can be an Explanation for Dysphagia of Otherwise Unknown Etiology

Pratik Naik, Yi Jia, Richard W. McCallum

Dysphagia and gastroesophageal reflux disease (GERD) are common entities in clinical practice. High-resolution manometry (HRM) of the esophagus is a diagnostic test to investigate dysphagia where other esophageal tests and evaluations had not disclosed an etiology. The goals of our study were to investigate the frequency of GERD in patients whose dysphagia cannot be explained by all prior studies including HRM and propose that GERD by inducing esophageal hypersensitivity could explain this sensation of dysphagia.



Departments Section


From the Literature

Long-Term Treatment of Eosinophilic Esophagitis

To evaluate whether long-lasting remission can be achieved in the treatment of eosinophilic esophagitis (EoE) and whether treatment can be stopped once patient has achieved remission, patients were included in a large database at the Swiss EoE Clinic since 2007 and were placed on swallowed topical corticosteroids (STCs) as induction/maintenance therapy.



PPI Use and Chronic Kidney Disease

A retrospective analysis was performed using the Stockholm creatinine measurements database, which contains information from diagnosis, dispensation claims and laboratory test results for all citizens in the Stockholm region from 2007 through 2010. New uses of PPIs were identified (N = 105,305), and new users of H2 blockers (H2B; N = 9578), data on renal outcomes were collected for a median 2.7 years.



PPI in Hemochromatosis

A randomized, controlled trial was carried out to prove that proton pump inhibitors (PPIs) reduce the need for phlebotomy in HFe-related hemochromatosis.



Aspirin, Clopidogrel, HBV and HCC

To determine whether anti-platelet therapy lowers the risk of HCC in patients with chronic hepatitis B, a retrospective analysis was conducted with data from 1674 chronic hepatitis B patients, enrolled between January 2002 and May 2015, whose serum hepatitis C virus DNA levels were suppressed by antivirals to less than 2000 international units.



Colorectal Cancer Screening Before Age 50

The fecal immunochemical test (FIT) is an alternative screening method for colorectal cancer in individuals less than 50 years. To determine the age at which commencing FIT is beneficial, records were reviewed from participants who had undergone a colonoscopy and FIT as part of the comprehensive health screening program.



Medical Bulletin Board

NEW ORLEANS SAINTS LINEBACKER KICKS OFF CROHN'S & COLITIS AWARENESS WEEK WITH MY CAUSE MY CLEATS

NEW YORK, NY-Crohn's & Colitis Awareness Week kicks off on December 1, and in recognition of the observance, New Orleans Saints linebacker Michael Mauti will dedicate his cleats during Week 13 of the NFL season to help raise awareness of these inflammatory bowel diseases (IBD) and the critical work of the Crohn's & Colitis Foundation to find cures for Crohn's disease and ulcerative colitis.



FUJIFILM PARTNERS WITH FIGHT COLORECTAL CANCER AS A SPONSOR OF ONE MILLION STRONG

Allendale, N.J., December, 2017 As part of its ongoing commitment to promoting early detection of colon cancer, FUJIFILM Medical Systems U.S.A., Inc. - Endoscopy announced its partnership with Fight Colorectal Cancer, the leading colorectal cancer advocacy organization. The two organizations will support a national movement called One Million Strong that brings together the strength of more than one million colorectal cancer survivors living in the United States



Meetings Calendar

Jan. 18-20, 2018 - The Crohn's & Colitis Congress
February 11-14, 2018 - The 2nd Annual The GUILD Conference 2018
May 19 - 23, 2018 - The 2018 American Society of Colon and Rectal Surgeons (ASCRS) Annual Scientific Meeting
June 2-5, 2018 - Digestive Disease Week (DDW)